HEREDITARY KIDNEY DISEASE
Polycystic Kidney Disease and Hereditary Nephritis
What the Kidneys do
The Kidneys primary function is to regulate the plasma and tissue fluid in the body by the formation of urine, quite simply the kidneys are filtering
harmful toxins from the body though the urine. In the process of urine formation the kidneys also regulate:
1. The volume of blood plasma and thus significantly to the regulation of blood pressure,
2. The concentration of waste products in the blood,
3. The concentration of electrolytes and other ions in the plasma and
4. The pH of plasma
So if the kidneys do not work correctly it can have a devastating effect on the whole body.
WHAT IS POLYCYSTIC KIDNEY DISEASE
Polycystic kidney disease (PKD) is an inherited disease characterized by the growth of numerous cysts filled with fluid in the kidneys. PKD cysts can
slowly replace much of the mass of kidneys, reducing kidney function and leading to kidney failure.
There is no cure for Polycystic kidney disease some diets may slow down the speed of the kidney degeneration however the final result is death from
kidney failure.
Mode of inheritance
Polycystic kidney disease is a autosomal dominant hereditary disease, which means that one or both of the parents have the gene and will pass it on to
up to 90% of the litter.The disorder can be readily eliminated by avoiding the breeding of affected individuals.
Testing for Polycystic kidney disease
Testing for Polycystic kidney disease is by renal ultrasound, which demonstrates the presence of fluid -filled cysts in the cortices and medullae of the
kidney
WHAT IS HEREDITARY NEPHRITIS:
Hereditary Nephritis is inherited in an autosomal dominant manner and is characterised by glomerulopathy, progressive renal atrophy and renal failure
at varying ages.
Mode of inheritance .
Hereditary Nephritis is an autosomal hereditary disease which may be inherited from either parent, is reqiured to produce the trait. The parent with the
dominant trait will pass the affected gene to approximately half the offspring, and the trait will be apparent in both the parent and the affected progeny.
The disorder can be readily eliminated by avoiding the breeding of affected individuals.
Testing for Hereditary Nephritis:
Testing is by the collection of a midstream urine sample ( the first of the day ) in a sterile pot and sent to the lab for Protein:creatinine ratio analysis. The
UPC will be returned within 24 hours and should be 0.3 or under. UPC of over 0.3 does not mean the dog has hereditary Nephritis and tests should be
preformed to rule out renal tract infection.
IN BOTH POLYCYSTIC KIDNEY AND HEREDITARY NEPHRITIS IT IS IMPORTANT TO TEST BOTH DOGS AND
BITCHES AFTER THE AGE OF 1 YEAR
Polycystic Kidney Disease and Hereditary Nephritis
What the Kidneys do
The Kidneys primary function is to regulate the plasma and tissue fluid in the body by the formation of urine, quite simply the kidneys are filtering
harmful toxins from the body though the urine. In the process of urine formation the kidneys also regulate:
1. The volume of blood plasma and thus significantly to the regulation of blood pressure,
2. The concentration of waste products in the blood,
3. The concentration of electrolytes and other ions in the plasma and
4. The pH of plasma
So if the kidneys do not work correctly it can have a devastating effect on the whole body.
WHAT IS POLYCYSTIC KIDNEY DISEASE
Polycystic kidney disease (PKD) is an inherited disease characterized by the growth of numerous cysts filled with fluid in the kidneys. PKD cysts can
slowly replace much of the mass of kidneys, reducing kidney function and leading to kidney failure.
There is no cure for Polycystic kidney disease some diets may slow down the speed of the kidney degeneration however the final result is death from
kidney failure.
Mode of inheritance
Polycystic kidney disease is a autosomal dominant hereditary disease, which means that one or both of the parents have the gene and will pass it on to
up to 90% of the litter.The disorder can be readily eliminated by avoiding the breeding of affected individuals.
Testing for Polycystic kidney disease
Testing for Polycystic kidney disease is by renal ultrasound, which demonstrates the presence of fluid -filled cysts in the cortices and medullae of the
kidney
WHAT IS HEREDITARY NEPHRITIS:
Hereditary Nephritis is inherited in an autosomal dominant manner and is characterised by glomerulopathy, progressive renal atrophy and renal failure
at varying ages.
Mode of inheritance .
Hereditary Nephritis is an autosomal hereditary disease which may be inherited from either parent, is reqiured to produce the trait. The parent with the
dominant trait will pass the affected gene to approximately half the offspring, and the trait will be apparent in both the parent and the affected progeny.
The disorder can be readily eliminated by avoiding the breeding of affected individuals.
Testing for Hereditary Nephritis:
Testing is by the collection of a midstream urine sample ( the first of the day ) in a sterile pot and sent to the lab for Protein:creatinine ratio analysis. The
UPC will be returned within 24 hours and should be 0.3 or under. UPC of over 0.3 does not mean the dog has hereditary Nephritis and tests should be
preformed to rule out renal tract infection.
IN BOTH POLYCYSTIC KIDNEY AND HEREDITARY NEPHRITIS IT IS IMPORTANT TO TEST BOTH DOGS AND
BITCHES AFTER THE AGE OF 1 YEAR
| Showing blood entering the kidney being filtered,and returned, with waste being removed as urine |
| Heart |
| Patella |
| Hearing |
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